Measuring windows of selection for anti-malarial drug treatments

Repurposing the anti-malarial drug, quinacrine: new anti-colitis properties

BACKGROUND Ulcerative colitis (UC) is a chronic inflammatory bowel disease that is associated with an increased risk of colorectal cancer in 8-10 years after disease onset. Current colitis treatment strategies do not offer a cure for the disease, but only treat the symptoms with limited success and dangerous side-effects. Also, there is no preventive treatment for either UC or colorectal cancer...

Present Position of Anti-Malarial Drug Therapy in India

Selection strength and hitchhiking around two anti-malarial resistance genes.

Neutral mutations may hitchhike to high frequency when they are situated close to sites under positive selection, generating local reductions in genetic diversity. This process is thought to be an important determinant of levels of genomic variation in natural populations. The size of genome regions affected by genetic hitchhiking is expected to be dependent on the strength of selection, but th...

A new anti-malarial drug against murine malaria

Eosin B, a common laboratory dye has been earlier reported to have good anti protozoan properties in vitro. We studied this drug for its effect on a murine malaria strain, Plasmodium berghei (Pb) in vivo using different tests. Full suppressive 4 days Peter’s Test was used in infected outbred and inbred mice, using both ip and oral routes. Secondary biological assessment was carried out using do...

Anti-malarial Drug Design by Targeting Apicoplasts: New Perspectives

OBJECTIVES Malaria has been a major global health problem in recent times with increasing mortality. Current treatment methods include parasiticidal drugs and vaccinations. However, resistance among malarial parasites to the existing drugs has emerged as a significant area of concern in anti-malarial drug design. Researchers are now desperately looking for new targets to develop anti-malarials ...